InvivoGen’s Reviews
Innate Immunity
TLR3: racing for vaccine advantages
Toll-like receptors (TLRs) play a pivotal role in the initiation of prompt innate immune defenses, as well as in the activation of adaptive immune cells for enhanced and memory responses. Thus, TLR agonists are attractive candidates for vaccine adjuvants and cancer therapeutics
Previous reviews
Inflammasome
NLRP1 & NLRP3: a tale of two inflammasome sensors
In this first newsletter of 2023, InvivoGen highlights the current knowledge about the NLRP1 and NLRP3 inflammasome sensors and discusses the experimental difficulty in assessing their respective role in pathophysiological contexts.
We also introduce a series of new products, including NLRP1 reporter cell lines, TLR4 reporter cell lines, as well as a new liquid formulation of our...
Innate Immunity / PRR / Inflammasome
NLRP3: a sophisticated drug target
NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryopyrin or NALP3) is the best described inflammasome sensor and an attractive drug target. NLRP3 assembles into a multiprotein inflammasome complex to induce the secretion of IL-1β/IL-18 and pyroptosis in response to infections and cellular damage. However, NLRP3 inflammasome functions can also be detrimental to the host, as its...
Innate Immunity / Inflammasome / PRR
Inflammasomes : connecting innate and adaptive immunity
Fifteen years ago, the discovery of inflammasomes was a breakthrough in our comprehension of how inflammation is set off. Inflammasomes have since been shown to play key roles in various pathophysiologic conditions and therefore constitute a major target for drug development.
This review focuses on the central function of inflammasomes between innate and adaptive immunity.
Innate Immunity / Inflammasome
Inflammasome activation: a matter of caspases
Inflammasomes are multimeric protein complexes that are crucial for host defense to infection and endogenous danger signals. They promote the secretion of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and cause a rapid and pro-inflammatory form of cell death called pyroptosis.
Innate Immunity / Inflammasome
Inflammasomes
The nucleotide-binding oligomerization domain-like receptor (NLR) family of proteins is involved in the regulation of innate immunity responses.
Innate Immunity / Inflammasome
Activation of the NLRP3 Inflammasome
The inflammasome is a large multiprotein complex which plays a key role in innate immunity by participating in the production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18.