CLR Ligands

Dectin-1, Dectin-2, and Mincle Agonists

Dectin-1 is a specific receptor of β-glucans, which are glucose polymers found in the cell walls of fungi, including the yeasts Saccharomyces cerevisiae and Candida albicans.

All Dectin-1 ligands are tested for Dectin-1 stimulation using Raw-Blue™ reporter cells.

Dectin-2 binds to mannose carbohydrates, such as the mannose-capped lipoarabinomannan of mycobacteria and α-mannans found in Candida albicans.

Mincle is a multi-task danger receptor that recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria.