Multi-PRR Ligands

InvivoGen has developed a series of novel molecules designed to induce potent immune responses through the combined activation of several pattern recognition receptors (PRRs) that trigger different innate immune signaling pathways.

These molecules are agonists for TLR2, TLR7 or both.

In addition, some of these ligands have the ability to form complexes with nucleic acids (for example, double-stranded DNA, such as short oligonucleotides or plasmid DNA, or single-stranded RNA) and facilitate their penetration into the cell resulting in their recognition by additional PRRs that sense nucleic acids (e.g. the cytosolic DNA sensors DDX41 and IFI16 and the dsRNA receptors TLR3 and RIG-I/MDA-5).

 

Read our review on Multi-PRR Ligands